Cholesterol and Sphingomyelin Drive Ligand-independent T-cell Antigen Receptor Nanoclustering

The T-cell antigen receptor (TCR) exists in monomeric and nanoclustered forms independently of antigen binding. Although the clustering is involved in the regulation of T-cell sensitivity, it is unknown how the TCR nanoclusters form. We show that cholesterol is required for TCR nanoclustering in T c...

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Autores principales: Molnár, Eszter, Swamy, Mahima, Holzer, Martin, Beck-García, Katharina, Worch, Remigiusz, Thiele, Christoph, Guigas, Gernot, Boye, Kristian, Luescher, Immanuel F., Schwille, Petra, Schubert, Rolf, Schamel, Wolfgang W. A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Membrane Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522267/
https://ncbi.nlm.nih.gov/pubmed/23091059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.386045
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