Cholesterol and Sphingomyelin Drive Ligand-independent T-cell Antigen Receptor Nanoclustering

The T-cell antigen receptor (TCR) exists in monomeric and nanoclustered forms independently of antigen binding. Although the clustering is involved in the regulation of T-cell sensitivity, it is unknown how the TCR nanoclusters form. We show that cholesterol is required for TCR nanoclustering in T c...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Molnár, Eszter, Swamy, Mahima, Holzer, Martin, Beck-García, Katharina, Worch, Remigiusz, Thiele, Christoph, Guigas, Gernot, Boye, Kristian, Luescher, Immanuel F., Schwille, Petra, Schubert, Rolf, Schamel, Wolfgang W. A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Membrane Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522267/
https://ncbi.nlm.nih.gov/pubmed/23091059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.386045
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares