Affinofile Profiling: How efficiency of CD4/CCR5 usage impacts the biological and pathogenic phenotype of HIV

HIV-1 envelope (Env) uses CD4 and a coreceptor (CCR5 and/or CXCR4) for viral entry. The efficiency of receptor/coreceptor mediated entry has important implications for HIV pathogenesis and transmission. The advent of CCR5 inhibitors in clinical use also underscores the need for quantitative and pred...

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Bibliographic Details
Main Authors: Chikere, Kelechi, Chou, Tom, Gorry, Paul R., Lee, Benhur
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522187/
https://ncbi.nlm.nih.gov/pubmed/23217618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.09.043
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