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Affinofile Profiling: How efficiency of CD4/CCR5 usage impacts the biological and pathogenic phenotype of HIV
HIV-1 envelope (Env) uses CD4 and a coreceptor (CCR5 and/or CXCR4) for viral entry. The efficiency of receptor/coreceptor mediated entry has important implications for HIV pathogenesis and transmission. The advent of CCR5 inhibitors in clinical use also underscores the need for quantitative and pred...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3522187/ https://ncbi.nlm.nih.gov/pubmed/23217618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.09.043 |
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