Catechol-O-Methyltransferase (COMT) Modulation of Cortisol Secretion in Psychiatrically At-risk and Healthy Adolescents

Recent research implicates the COMT Val(108/158)Met polymorphism in stress-sensitivity, via modulation of hypothalamic-pituitary-adrenal (HPA) function. In healthy samples, Met-homozygosity has been associated with greater HPA activity (i.e., cortisol) and stress sensitivity, though findings are mix...

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Main Authors: Walder, Deborah J., Trotman, Hanan D., Cubells, Joseph F., Brasfield, Joy, Tang, Yilang, Walker, Elaine F.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522124/
https://ncbi.nlm.nih.gov/pubmed/20421850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/YPG.0b013e32833a1ff3
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