Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls

OBJECTIVE: Cognitive impairment is a core feature of schizophrenia, related to dopaminergic dysfunction in the prefrontal cortex (PFC). It is hypothesized that functional single nucleotide polymorphism (SNP) rs4680 of the catechol-O-methyltransferase (COMT) gene could mediate the relationship betwee...

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Detaylı Bibliyografya
Yayımlandı:Braz J Psychiatry
Asıl Yazarlar: Matsuzaka, Camila T., Christofolini, Denise, Ota, Vanessa K., Gadelha, Ary, Berberian, Arthur A., Noto, Cristiano, Mazzotti, Diego R., Spindola, Leticia M., Moretti, Patricia N., Smith, Marilia A.C., Melaragno, Maria I., Belangero, Sintia I.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Associação Brasileira de Psiquiatria 2017
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7111404/
https://ncbi.nlm.nih.gov/pubmed/28273278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/1516-4446-2016-1987
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