Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls

OBJECTIVE: Cognitive impairment is a core feature of schizophrenia, related to dopaminergic dysfunction in the prefrontal cortex (PFC). It is hypothesized that functional single nucleotide polymorphism (SNP) rs4680 of the catechol-O-methyltransferase (COMT) gene could mediate the relationship betwee...

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Pubblicato in:Braz J Psychiatry
Autori principali: Matsuzaka, Camila T., Christofolini, Denise, Ota, Vanessa K., Gadelha, Ary, Berberian, Arthur A., Noto, Cristiano, Mazzotti, Diego R., Spindola, Leticia M., Moretti, Patricia N., Smith, Marilia A.C., Melaragno, Maria I., Belangero, Sintia I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Associação Brasileira de Psiquiatria 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7111404/
https://ncbi.nlm.nih.gov/pubmed/28273278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/1516-4446-2016-1987
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