A PGC1α-dependent myokine that drives browning of white fat and thermogenesis

Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional coactivator PGC1α Here we show that PGC1α expression in muscle stimulates an increase in expression of Fndc5, a membrane protein that is cleaved...

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Main Authors: Boström, Pontus, Wu, Jun, Jedrychowski, Mark P., Korde, Anisha, Ye, Li, Lo, James C., Rasbach, Kyle A., Boström, Elisabeth Almer, Choi, Jang Hyun, Long, Jonathan Z., Kajimura, Shingo, Zingaretti, Maria Cristina, Vind, Birgitte F., Tu, Hua, Cinti, Saverio, Højlund, Kurt, Gygi, Steven P., Spiegelman, Bruce M.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522098/
https://ncbi.nlm.nih.gov/pubmed/22237023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10777
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