A PGC1α-dependent myokine that drives browning of white fat and thermogenesis

Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional coactivator PGC1α Here we show that PGC1α expression in muscle stimulates an increase in expression of Fndc5, a membrane protein that is cleaved...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Boström, Pontus, Wu, Jun, Jedrychowski, Mark P., Korde, Anisha, Ye, Li, Lo, James C., Rasbach, Kyle A., Boström, Elisabeth Almer, Choi, Jang Hyun, Long, Jonathan Z., Kajimura, Shingo, Zingaretti, Maria Cristina, Vind, Birgitte F., Tu, Hua, Cinti, Saverio, Højlund, Kurt, Gygi, Steven P., Spiegelman, Bruce M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522098/
https://ncbi.nlm.nih.gov/pubmed/22237023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10777
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