A UV-independent pathway to melanoma carcinogenesis in the redhair-fairskin background

People with pale skin, red hair, freckles, and an inability to tan—the “redhair/fairskin” phenotype— are at highest risk of developing melanoma, compared to all other pigmentation types(1). Genetically, this phenotype is frequently the product of inactivating polymorphisms in the Melanocortin 1 rece...

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Main Authors: Mitra, Devarati, Luo, Xi, Morgan, Ann, Wang, Jin, Hoang, Mai P., Lo, Jennifer, Guerrero, Candace R., Lennerz, Jochen K., Mihm, Martin C., Wargo, Jennifer A., Robinson, Kathleen C., Devi, Suprabha P., Vanover, Jillian C., D’Orazio, John A., McMahon, Martin, Bosenberg, Marcus W., Haigis, Kevin M., Haber, Daniel A., Wang, Yinsheng, Fisher, David E.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521494/
https://ncbi.nlm.nih.gov/pubmed/23123854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11624
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