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A semi-supervised boosting SVM for predicting hot spots at protein-protein Interfaces

BACKGROUND: Hot spots are residues contributing the most of binding free energy yet accounting for a small portion of a protein interface. Experimental approaches to identify hot spots such as alanine scanning mutagenesis are expensive and time-consuming, while computational methods are emerging as...

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Hlavní autoři: Xu, Bin, Wei, Xiaoming, Deng, Lei, Guan, Jihong, Zhou, Shuigeng
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521187/
https://ncbi.nlm.nih.gov/pubmed/23282146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-6-S2-S6
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