Desensitization, Trafficking, and Resensitization of the Pituitary Thyrotropin-Releasing Hormone Receptor

The pituitary receptor for thyrotropin-releasing hormone (TRH) is a calcium-mobilizing G protein-coupled receptor (GPCR) that signals through Gq/11, elevating calcium, and activating protein kinase C. TRH receptor signaling is quickly desensitized as a consequence of receptor phosphorylation, arrest...

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Bibliographic Details
Main Authors: Hinkle, Patricia M., Gehret, Austin U., Jones, Brian W.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2012
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521152/
https://ncbi.nlm.nih.gov/pubmed/23248581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2012.00180
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