Role of Helix 8 of the Thyrotropin-Releasing Hormone Receptor in Phosphorylation by G Protein-Coupled Receptor Kinase

The thyrotropin-releasing hormone (TRH) receptor undergoes rapid and extensive agonist-dependent phosphorylation attributable to G protein-coupled receptor (GPCR) kinases (GRKs), particularly GRK2. Like many GPCRs, the TRH receptor is predicted to form an amphipathic helix, helix 8, between the NPXX...

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Main Authors: Gehret, Austin U., Jones, Brian W., Tran, Phuong N., Cook, Laurie B., Greuber, Emileigh K., Hinkle, Patricia M.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2010
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812072/
https://ncbi.nlm.nih.gov/pubmed/19906838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.059733
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