Importance of regions outside the cytoplasmic tail of G-protein-coupled receptors for phosphorylation and dephosphorylation

Two GPCRs (G-protein-coupled receptors), TRHR (thyrotropin-releasing hormone receptor) and β(2)AR (β(2)-adrenergic receptor), are regulated in distinct manners. Following agonist binding, TRHR undergoes rapid phosphorylation attributable to GRKs (GPCR kinases); β(2)AR is phosphorylated by both secon...

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Bibliographic Details
Main Authors: GEHRET, Austin U., HINKLE, Patricia M.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992812/
https://ncbi.nlm.nih.gov/pubmed/20345371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20100139
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