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Leptin Overexpression in VTA Trans-activates the Hypothalamus whereas Prolonged Leptin Action in either Region Cross-Desensitizes

High-fat feeding or CNS leptin overexpression in chow-fed rats results in a region-specific cellular leptin resistance in medial basal hypothalamic regions and the ventral tegmental area (VTA). The present investigation examined the effects of targeted chronic leptin overexpression in the VTA as com...

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Autors principals: Scarpace, P. J., Matheny, M., Kirichenko, N.V., Gao, Y.X., Tümer, N., Zhang, Y.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521099/
https://ncbi.nlm.nih.gov/pubmed/22982569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2012.09.005
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