Inhibition of Influenza Virus Ribonucleic Acid Polymerase by Ribavirin Triphosphate

Ribavirin 5′-triphosphate (RTP), derived from the broad-spectrum antiviral compound ribavirin (Virazole), can selectively inhibit influenza virus ribonucleic acid polymerase in a cell-free assay. Ribavirin and its 5′-monophosphate have no effect on the polymerase. The inhibition is competitive with...

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Bibliografische Detailangaben

Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Eriksson, Bertil, Helgstrand, Erik, Johansson, Nils Gunnar, Larsson, Alf, Misiorny, Alfons, Noren, Jan Olof, Philipson, Lennart, Stenberg, Kjell, Stening, Goran, Stridh, Stig, Öberg, Bo
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1977
Schlagworte:	Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352108/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/879760/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.11.6.946
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