Inhibition of Influenza Virus Ribonucleic Acid Polymerase by Ribavirin Triphosphate

Ribavirin 5′-triphosphate (RTP), derived from the broad-spectrum antiviral compound ribavirin (Virazole), can selectively inhibit influenza virus ribonucleic acid polymerase in a cell-free assay. Ribavirin and its 5′-monophosphate have no effect on the polymerase. The inhibition is competitive with...

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Main Authors: Eriksson, Bertil, Helgstrand, Erik, Johansson, Nils Gunnar, Larsson, Alf, Misiorny, Alfons, Noren, Jan Olof, Philipson, Lennart, Stenberg, Kjell, Stening, Goran, Stridh, Stig, Öberg, Bo
Format: Artigo
Jezik:Inglês
Izdano: 1977
Teme:
Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC352108/
https://ncbi.nlm.nih.gov/pubmed/879760
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