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A Sialyltransferase Mutant with Decreased Donor Hydrolysis and Reduced Sialidase Activities for Directly Sialylating Lewis(x)

Glycosyltransferases are important catalysts for enzymatic and chemoenzymatic synthesis of complex carbohydrates and glycoconjugates. The glycosylation efficiencies of wild-type glycosyltransferases vary considerably when different acceptor substrates were used. Using a multifunctional Pasteurella m...

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Detalhes bibliográficos
Main Authors: Sugiarto, Go, Lau, Kam, Qu, Jingyao, Li, Yanhong, Lim, Sunghyuk, Mu, Shengmao, Ames, James B., Fisher, Andrew J., Chen, Xi
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521065/
https://ncbi.nlm.nih.gov/pubmed/22583967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300125k
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