A Sialyltransferase Mutant with Decreased Donor Hydrolysis and Reduced Sialidase Activities for Directly Sialylating Lewis(x)

Glycosyltransferases are important catalysts for enzymatic and chemoenzymatic synthesis of complex carbohydrates and glycoconjugates. The glycosylation efficiencies of wild-type glycosyltransferases vary considerably when different acceptor substrates were used. Using a multifunctional Pasteurella m...

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Autori principali: Sugiarto, Go, Lau, Kam, Qu, Jingyao, Li, Yanhong, Lim, Sunghyuk, Mu, Shengmao, Ames, James B., Fisher, Andrew J., Chen, Xi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521065/
https://ncbi.nlm.nih.gov/pubmed/22583967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300125k
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