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Hedgehog signaling blockade delays hepatocarcinogenesis induced by hepatitis B virus X (HBx) protein

The hepatitis B virus (HBV) encoded X protein (HBx) contributes centrally to the pathogenesis of hepatocellular carcinoma (HCC). Aberrant activation of the Hedgehog (Hh) pathway has been linked to many tumor types including HCC. Thus, experiments were designed to test the hypothesis that HBx promote...

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Hlavní autoři: Arzumanyan, Alla, Sambandam, Vaishnavi, Clayton, Marcia M., Choi, Steve S., Xie, Guanhua, Diehl, Anna Mae, Yu, Dae-Yeul, Feitelson, Mark A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521045/
https://ncbi.nlm.nih.gov/pubmed/22986746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2329
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