Hedgehog signaling blockade delays hepatocarcinogenesis induced by hepatitis B virus X (HBx) protein

The hepatitis B virus (HBV) encoded X protein (HBx) contributes centrally to the pathogenesis of hepatocellular carcinoma (HCC). Aberrant activation of the Hedgehog (Hh) pathway has been linked to many tumor types including HCC. Thus, experiments were designed to test the hypothesis that HBx promote...

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Bibliografiske detaljer
Main Authors: Arzumanyan, Alla, Sambandam, Vaishnavi, Clayton, Marcia M., Choi, Steve S., Xie, Guanhua, Diehl, Anna Mae, Yu, Dae-Yeul, Feitelson, Mark A.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521045/
https://ncbi.nlm.nih.gov/pubmed/22986746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2329
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