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Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2
Numerous p53 missense mutations possess gain-of-function activities. Studies in mouse models have demonstrated that the stabilization of p53 R172H (R175H in human) mutant protein, by currently unknown factors, is a prerequisite for its oncogenic gain-of-function phenotype such as tumour progression...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3520893/ https://ncbi.nlm.nih.gov/pubmed/23251530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051426 |
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