Incorporation of paramagnetic, fluorescent and PET/SPECT contrast agents into liposomes for multimodal imaging

A series of metal-chelating lipid conjugates has been designed and synthesized. Each member of the series bears a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) macrocycle attached to the lipid head group, using short n-ethylene glycol (n-EG) spacers of varying length. Liposomes inc...

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Detalhes bibliográficos
Main Authors: Mitchell, Nick, Kalber, Tammy L., Cooper, Margaret S., Sunassee, Kavitha, Chalker, Samantha L., Shaw, Karen P., Ordidge, Katherine L., Badar, Adam, Janes, Samuel M., Blower, Philip J., Lythgoe, Mark F., Hailes, Helen C., Tabor, Alethea B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520009/
https://ncbi.nlm.nih.gov/pubmed/23131536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2012.09.070
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