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JP-45/JSRP1 variants affect skeletal muscle excitation contraction coupling by decreasing the sensitivity of the dihydropyridine receptor

JP-45 (also JP45; encoded by JSRP1) is an integral protein constituent of the skeletal muscle sarcoplasmic reticulum junctional face membrane interacting with Ca(v)1.1 (the α.1 subunit of the voltage sensing dihydropyridine receptor, DHPR) and the luminal calcium-binding protein calsequestrin. Two J...

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Detalhes bibliográficos
Main Authors: Yasuda, Toshimichi, Delbono, Osvaldo, Wang, Zhong-Min, Messi, Maria L., Girard, Thierry, Urwyler, Albert, Treves, Susan, Zorzato, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519957/
https://ncbi.nlm.nih.gov/pubmed/22927026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.22209
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