MLH1 Region Polymorphisms Show a Significant Association with CpG Island Shore Methylation in a Large Cohort of Healthy Individuals

Single nucleotide polymorphisms (SNPs) are the most common form of genetic variation. We previously demonstrated that SNPs (rs1800734, rs749072, and rs13098279) in the MLH1 gene region are associated with MLH1 promoter island methylation, loss of MLH1 protein expression, and microsatellite instabili...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Savio, Andrea J., Lemire, Mathieu, Mrkonjic, Miralem, Gallinger, Steven, Zanke, Brent W., Hudson, Thomas J., Bapat, Bharati
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519863/
https://ncbi.nlm.nih.gov/pubmed/23240038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051531
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