Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis

BACKGROUND: Mutations in the gene encoding the RNA-binding protein fused in sarcoma (FUS) can cause familial and sporadic amyotrophic lateral sclerosis (ALS) and rarely frontotemproal dementia (FTD). FUS accumulates in neuronal cytoplasmic inclusions (NCIs) in ALS patients with FUS mutations. FUS is...

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Bibliografische gegevens
Hoofdauteurs: Verbeeck, Christophe, Deng, Qiudong, DeJesus-Hernandez, Mariely, Taylor, Georgia, Ceballos-Diaz, Carolina, Kocerha, Jannet, Golde, Todd, Das, Pritam, Rademakers, Rosa, Dickson, Dennis W, Kukar, Thomas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2012
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519790/
https://ncbi.nlm.nih.gov/pubmed/23046583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-53
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