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Linkage disequilibrium analysis reveals an albuminuria risk haplotype containing three missense mutations in the cubilin gene with striking differences among European and African ancestry populations

BACKGROUND: A recent meta-analysis described a variant (p.Ile2984Val) in the cubilin gene (CUBN) that is associated with levels of albuminuria in the general population and in diabetics. METHODS: We implemented a Linkage Disequilibrium (LD) search with data from the 1000 Genomes Project, on African...

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Bibliografiske detaljer
Main Authors: Tzur, Shay, Wasser, Walter G, Rosset, Saharon, Skorecki, Karl
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519576/
https://ncbi.nlm.nih.gov/pubmed/23114252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2369-13-142
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