Effect of trifluoperazine on toxicity, HIF-1α induction and hepatocyte regeneration in acetaminophen toxicity in mice()

Oxidative stress and mitochondrial permeability transition (MPT) are important mechanisms in acetaminophen (APAP) toxicity. The MPT inhibitor trifluoperazine (TFP) reduced MPT, oxidative stress, and toxicity in freshly isolated hepatocytes treated with APAP. Since hypoxia inducible factor-one alpha...

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Détails bibliographiques
Auteurs principaux: Chaudhuri, Shubhra, McCullough, Sandra S., Hennings, Leah, Brown, Aliza T., Li, Shun-Hwa, Simpson, Pippa M., Hinson, Jack A., James, Laura P.
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519387/
https://ncbi.nlm.nih.gov/pubmed/22902588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2012.08.001
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