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Evolutionary Diversity of the Mitochondrial Calcium Uniporter

Calcium uptake into mitochondria occurs via a recently identified ion channel called the uniporter. Here, we characterize the phylogenomic distribution of the uniporter’s membrane-spanning pore subunit (MCU) and regulatory partner (MICU1). Homologs of both components tend to co-occur in all major br...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Bick, Alexander G., Calvo, Sarah E., Mootha, Vamsi K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518847/
https://ncbi.nlm.nih.gov/pubmed/22605770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1214977
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