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HSP90 inhibitor antagonizing MIF: The specifics of pleiotropic cancer drug candidates

Constitutively stabilized HSP90 client proteins are crucial for cancer cell survival and proliferation. Thus, despite—or perhaps because of—their pleiotropic effects on variety of critical oncoproteins, HSP90 inhibitors represent a promising new class of anticancer drugs. We identified MIF as an ess...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Schulz, Ramona, Dobbelstein, Matthias, Moll, Ute M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Landes Bioscience 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518525/
https://ncbi.nlm.nih.gov/pubmed/23243616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.21173
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