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Functional differences between low- and high-affinity CD8(+) T cells in the tumor environment
Weak T-cell antigen receptor (TCR)-ligand interactions are sufficient to activate naïve CD8(+) T cells, but generally do not result in tumor eradication. How differences in TCR affinity affect the regulation of T-cell function in an immunosuppressive tumor environment has not been investigated. We h...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3518496/ https://ncbi.nlm.nih.gov/pubmed/23243587 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.21285 |
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