Sequential post-translational modifications program FEN1 degradation during cell cycle progression

We propose that cell cycle-dependent timing of FEN1 nuclease activity is essential for cell cycle progression and the maintenance of genome stability. After DNA replication is complete at the exit point of the S-phase, removal of excess FEN1 may be crucial. Here, we report a mechanism that controls...

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書誌詳細
主要な著者: Guo, Zhigang, Kanjanapangka, Julie, Liu, Na, Liu, Songbai, Liu, Changwei, Wu, Zhenxing, Wang, Yingjie, Loh, Tiffany, Kowolik, Claudia, Jamsen, Joonas, Zhou, Mian, Truong, Khue, Chen, Yuan, Zheng, Li, Shen, Binghui
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518404/
https://ncbi.nlm.nih.gov/pubmed/22749529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.05.042
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