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Base damage immediately upstream from double-strand break ends is a more severe impediment to nonhomologous end joining than blocked 3′-termini
Radiation-induced DNA double-strand breaks (DSBs) are critical cytotoxic lesions that are typically repaired by nonhomologous end joining (NHEJ) in human cells. Our previous work indicates the highly cytotoxic DSBs formed by (125)I decay possess base damage clustered within 8 to 10 bases of the brea...
সংরক্ষণ করুন:
| প্রধান লেখক: | , , , , |
|---|---|
| বিন্যাস: | Artigo |
| ভাষা: | Inglês |
| প্রকাশিত: |
2011
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3518376/ https://ncbi.nlm.nih.gov/pubmed/21175352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR2332.1 |
| ট্যাগগুলো: |
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