Coincident In Vitro Analysis of DNA-PK-Dependent and -Independent Nonhomologous End Joining

In mammalian cells, DNA double-strand breaks (DSBs) are primarily repaired by nonhomologous end joining (NHEJ). The current model suggests that the Ku 70/80 heterodimer binds to DSB ends and recruits DNA-PK(cs) to form the active DNA-dependent protein kinase, DNA-PK. Subsequently, XRCC4, DNA ligase...

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Autori principali: Hendrickson, Cynthia L., Purkayastha, Shubhadeep, Pastwa, Elzbieta, Neumann, Ronald D., Winters, Thomas A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: SAGE-Hindawi Access to Research 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919755/
https://ncbi.nlm.nih.gov/pubmed/20706599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2010/823917
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