Impact of intertumoral heterogeneity on predicting chemotherapy response of BRCA1-deficient mammary tumors

The lack of markers to predict chemotherapy responses in patients poses a major handicap in cancer treatment. We searched for gene expression patterns that correlate with docetaxel or cisplatin response in a mouse model for breast cancer associated with BRCA1 deficiency. Array-based expression profi...

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Huvudupphovsmän: Rottenberg, Sven, Vollebergh, Marieke A., de Hoon, Bas, de Ronde, Jorma, Schouten, Philip C., Kersbergen, Ariena, Zander, Serge A.L., Pajic, Marina, Jaspers, Janneke E., Jonkers, Martijn, Lodén, Martin, Sol, Wendy, van der Burg, Eline, Wesseling, Jelle, Gillet, Jean-Pierre, Gottesman, Michael M., Gribnau, Joost, Wessels, Lodewyk, Linn, Sabine C., Jonkers, Jos, Borst, Piet
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518318/
https://ncbi.nlm.nih.gov/pubmed/22396490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-4201
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