Stimulation of Adrenal Chromaffin Cell Proliferation by Hypercalcemia Induced by Intravenous Infusion of Calcium Gluconate in Rats

Increased incidence of adrenal pheochromocytoma is frequently encountered in rat carcinogenicity studies. In some of the studies, the finding is judged to be due to a rat-specific mechanism of carcinogenesis caused by a disturbance of calcium homeostasis. However, direct evidence that the proliferat...

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Main Authors: Isobe, Kaori, Ito, Tsuneo, Komatsu, Shun-ichiro, Asanuma, Kentaro, Fujii, Etsuko, Kato, Chie, Adachi, Kenji, Kato, Atsuhiko, Sugimoto, Tetsuro, Suzuki, Masami
Format: Artigo
Jezik:Inglês
Izdano: Japanese Society of Toxicologic Pathology 2012
Teme:
Short Communication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517925/
https://ncbi.nlm.nih.gov/pubmed/23345932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1293/tox.25.281
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