Live cell studies of p300/CBP histone acetyltransferase activity and inhibition

Histone acetyltransferase enzymes (HATs) are important therapeutic targets, but there are few cell-based assays available for evaluating the pharmacodynamics of HAT inhibitors. Here we present the application of a FRET-based reporter, Histac, in live cell studies of p300/CBP HAT inhibition, by both...

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Detalhes bibliográficos
Main Authors: Dancy, Beverley M., Crump, Nicholas T., Peterson, Daniel J., Mukherjee, Chandrani, Bowers, Erin M., Ahn, Young-Hoon, Yoshida, Minoru, Zhang, Jin, Mahadevan, Louis C., Meyers, David J., Boeke, Jef D., Cole, Philip A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517098/
https://ncbi.nlm.nih.gov/pubmed/22961914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201200381
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