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Pyran Formation by an Atypical CYP-Mediated Four-Electron Oxygenation-Cyclization Cascade in an Engineered Aureothin Pathway

Small changes – big effect A new aureothin derivative, aureopyran, that features an unusual pyran backbone was generated by simply altering the enzymatic methylation topology. The α-pyrone ring hampers the correct placement of the polyketide backbone in the multifunctional cytochrome P450 monooxygen...

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Detaylı Bibliyografya
Asıl Yazarlar: Richter, Martin, Busch, Benjamin, Ishida, Keishi, Moore, Bradley S., Hertweck, Christian
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517090/
https://ncbi.nlm.nih.gov/pubmed/22961965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201200406
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