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Pyran Formation by an Atypical CYP-Mediated Four-Electron Oxygenation-Cyclization Cascade in an Engineered Aureothin Pathway
Small changes – big effect A new aureothin derivative, aureopyran, that features an unusual pyran backbone was generated by simply altering the enzymatic methylation topology. The α-pyrone ring hampers the correct placement of the polyketide backbone in the multifunctional cytochrome P450 monooxygen...
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Asıl Yazarlar: | , , , , |
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Materyal Türü: | Artigo |
Dil: | Inglês |
Baskı/Yayın Bilgisi: |
2012
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Konular: | |
Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3517090/ https://ncbi.nlm.nih.gov/pubmed/22961965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201200406 |
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