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Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases
Polyketides produced by modular type I polyketide synthases (PKSs) play eminent roles in the development of medicines. Yet, the production of structural analogs by genetic engineering poses a major challenge. We report an evolution-guided morphing of modular PKSs inspired by recombination processes...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6718629/ https://ncbi.nlm.nih.gov/pubmed/31477708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11896-1 |
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