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Total Synthesis of Laulimalide: Synthesis of the Northern and Southern Fragments
The first stage of the development of a synthetic route for the total synthesis of laulimalide (1) is described. Our retrosynthetic analysis envisioned a novel macrocyclization route to the natural product using a Ru-catalyzed alkene-alkyne coupling. This would be preceded by an esterification of th...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3517066/ https://ncbi.nlm.nih.gov/pubmed/22307837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201102898 |
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