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Total Synthesis of Laulimalide: Synthesis of the Northern and Southern Fragments

The first stage of the development of a synthetic route for the total synthesis of laulimalide (1) is described. Our retrosynthetic analysis envisioned a novel macrocyclization route to the natural product using a Ru-catalyzed alkene-alkyne coupling. This would be preceded by an esterification of th...

詳細記述

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書誌詳細
主要な著者: Trost, Barry M., Seganish, W. Michael, Chung, Cheol K., Amans, Dominique
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517066/
https://ncbi.nlm.nih.gov/pubmed/22307837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201102898
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