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Evaluating Transition-Metal Catalyzed Transformations for the Synthesis of Laulimalide

Laulimalide is a structurally unique 20-membered marine macrolide displaying microtubule stabilizing activity similar to that of paclitaxel and the epothilones. The use of atom economical transformations such as a rhodium-catalyzed cycloisomerization to form the endocyclic dihydropyran, a dinuclear...

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Autori principali: Trost, Barry M., Amans, Dominique, Seganish, W. Michael, Chung, Cheol K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791108/
https://ncbi.nlm.nih.gov/pubmed/19891433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja907924j
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