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Prediction of the 3D structure for the rat urotensin II receptor and comparison of the antagonist binding sites and binding selectivity between human and rat from atomistic simulations
Urotensin-II (U-II) has been shown to be the most potent mammalian vasoconstrictor known.([1, 2]) Thus a U-II antagonist might be of therapeutic value in a number of cardiovascular disorders.([3]) However, interspecies variability of several nonpeptidic ligands complicates the interpretation of in v...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3517062/ https://ncbi.nlm.nih.gov/pubmed/20683923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201000175 |
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