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Benzyl and Naphthalene-Methyl Phosphonic Acid Inhibitors of Autotaxin with Anti-invasive and Anti-metastatic Actions

Autotaxin (ATX, NPP2) is a member of the nucleotide pyrophosphate phosphodiesterase enzyme family. ATX catalyzes the hydrolytic cleavage of lysophosphatidylcholine (LPC) via a lysophospholipase D activity that leads to the generation of the growth factor-like lipid mediator lysophosphatidic acid (LP...

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Detalhes bibliográficos
Main Authors: Gupte, Renuka, Patil, Renukadevi, Liu, Jianxiong, Wang, Yaohong, Lee, Sue C., Fujiwara, Yuko, Fells, James, Bolen, Alyssa L., Emmons-Thompson, Karin, Yates, C. Ryan, Siddam, Anjaih, Panupinthu, Nattapon, Pham, Truc-Chi T., Baker, Daniel L., Parrill, Abby L., Mills, Gordon B., Tigyi, Gabor, Miller, Duane D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517046/
https://ncbi.nlm.nih.gov/pubmed/21465666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201000425
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