Mechanism of Fibrillation Inhibition of Amyloid Peptides by Inorganic Nanoparticles Reveal Functional Similarities with Proteins

Aggregation of amyloid-β peptides (Aβ) into fibrils is the key pathological feature of many neurodegenerative disorders. Typical drugs inhibit Aβ fibrillation by binding to monomers in 1:1 ratio and display low efficacy. Here, we report that model CdTe nanoparticles (NPs) can efficiently prevent fib...

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Bibliografiske detaljer
Main Authors: Yoo, Seong Il, Yang, Ming, Subramanian, Vivekanandan, Brender, Jeffrey R., Sun, Kai, Joo, Nam Eok, Jeong, Soo-Hwan, Ramamoorthy, Ayyalusamy, Kotov, Nicholas A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516928/
https://ncbi.nlm.nih.gov/pubmed/21495130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201007824
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