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Anti-Chromatin Antibodies Drive In Vivo Antigen-Specific Activation and Somatic Hypermutation of Rheumatoid Factor B cells at Extrafollicular Sites
A dominant type of spontaneous autoreactive B cell activation in murine lupus is the extrafollicular generation of plasmablasts. The factors governing such activation have been difficult to identify due to the stochastic onset and chronic nature of the response. Thus, the ability to induce a similar...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3516908/ https://ncbi.nlm.nih.gov/pubmed/18034429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200737752 |
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