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Mutations of Human Cytochrome P450 Reductase Differentially Modulate Heme Oxygenase-I Activity and Oligomerization
Genetic variations in POR, encoding NADPH-cytochrome P450 oxidoreductase (CYPOR), can diminish the function of numerous cytochromes P450, and also have the potential to block degradation of heme by heme oxygenase-I (HO-1). Purified full-length human CYPOR, HO-1, and biliverdin reductase were reconst...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3516858/ https://ncbi.nlm.nih.gov/pubmed/21741353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2011.06.008 |
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