Mutations of Human Cytochrome P450 Reductase Differentially Modulate Heme Oxygenase-I Activity and Oligomerization

Genetic variations in POR, encoding NADPH-cytochrome P450 oxidoreductase (CYPOR), can diminish the function of numerous cytochromes P450, and also have the potential to block degradation of heme by heme oxygenase-I (HO-1). Purified full-length human CYPOR, HO-1, and biliverdin reductase were reconst...

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Bibliographic Details
Main Authors: Marohnic, Christopher C., Huber, Warren J., Connick, J. Patrick, Reed, James R., McCammon, Karen, Panda, Satya P., Martásek, Pavel, Backes, Wayne L., Masters, Bettie Sue S.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516858/
https://ncbi.nlm.nih.gov/pubmed/21741353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2011.06.008
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