Serine 363 Is Required for Nociceptin/Orphanin FQ Opioid Receptor (NOPR) Desensitization, Internalization, and Arrestin Signaling

We determined the role of carboxyl-terminal regulation of NOPR (nociceptin, orphanin FQ receptor) signaling and function. We mutated C-terminal serine and threonine residues and examined their role in NOPR trafficking, homologous desensitization, and arrestin-dependent MAPK signaling. The NOPR agoni...

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Autors principals: Zhang, Nancy R., Planer, William, Siuda, Edward R., Zhao, Hu-Chen, Stickler, Lucy, Chang, Steven D., Baird, Madison A., Cao, Yu-Qing, Bruchas, Michael R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Neurobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516748/
https://ncbi.nlm.nih.gov/pubmed/23086955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.405696
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