Progression of Chronic Liver Inflammation and Fibrosis Driven by Activation of c-JUN Signaling in Sirt6 Mutant Mice

The human body has a remarkable ability to regulate inflammation, a biophysical response triggered by virus infection and tissue damage. Sirt6 is critical for metabolism and lifespan; however, its role in inflammation is unknown. Here we show that Sirt6-null (Sirt6(−/−)) mice developed chronic liver...

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Detalhes bibliográficos
Main Authors: Xiao, Cuiying, Wang, Rui-Hong, Lahusen, Tyler J., Park, Ogyi, Bertola, Adeline, Maruyama, Takashi, Reynolds, Della, Chen, Qiang, Xu, Xiaoling, Young, Howard A., Chen, Wan-Jun, Gao, Bin, Deng, Chu-Xia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516737/
https://ncbi.nlm.nih.gov/pubmed/23076146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.415182
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