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Chronic Pulsatile Hyperglycemia Reduces Insulin Secretion and Increases Accumulation of Reactive Oxygen Species in Fetal Sheep Islets

Children from diabetic pregnancies have a greater incidence of Type 2 diabetes. Our objective was to determine if exposure to mild-moderate hyperglycemia, modeling managed diabetic pregnancies, affects fetal β-cell function. In sheep fetuses β-cell responsiveness was examined after two weeks of sust...

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Detalhes bibliográficos
Main Authors: Green, Alice S., Chen, Xiaochuan, Macko, Antoni R., Anderson, Miranda J., Kelly, Amy C., Hart, Nathaniel J., Lynch, Ronald M., Limesand, Sean W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516619/
https://ncbi.nlm.nih.gov/pubmed/22182602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-11-0300
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