Evaluation of the Therapeutic Potential of a CNP Analog in a Fgfr3 Mouse Model Recapitulating Achondroplasia

Achondroplasia (ACH), the most common form of dwarfism, is an inherited autosomal-dominant chondrodysplasia caused by a gain-of-function mutation in fibroblast-growth-factor-receptor 3 (FGFR3). C-type natriuretic peptide (CNP) antagonizes FGFR3 downstream signaling by inhibiting the pathway of mitog...

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Autores principales: Lorget, Florence, Kaci, Nabil, Peng, Jeff, Benoist-Lasselin, Catherine, Mugniery, Emilie, Oppeneer, Todd, Wendt, Dan J., Bell, Sean M., Bullens, Sherry, Bunting, Stuart, Tsuruda, Laurie S., O'Neill, Charles A., Di Rocco, Federico, Munnich, Arnold, Legeai-Mallet, Laurence
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516592/
https://ncbi.nlm.nih.gov/pubmed/23200862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2012.10.014
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