Corneal Inflammation Is Inhibited by the LFA-1 Antagonist, Lifitegrast (SAR 1118)

Por Sun, Yan, Zhang, Rui, Gadek, Thomas R., O'Neill, Charles A., Pearlman, Eric
Publicado em 2013

Genetic variation in aryl N-acetyltransferase results in significant differences in the pharmacokinetic and safety profiles of amifampridine (3,4-diaminopyridine) phosphate

Por Haroldsen, Peter E, Garovoy, Marvin R, Musson, Donald G, Zhou, Huiyu, Tsuruda, Laurie, Hanson, Boyd, O’Neill, Charles A
Publicado no Pharmacol Res Perspect (2015)

Pharmacokinetic and Pharmacodynamic Evaluation of Elosulfase Alfa, an Enzyme Replacement Therapy in Patients with Morquio A Syndrome

Por Qi, Yulan, Musson, Donald G., Schweighardt, Becky, Tompkins, Troy, Jesaitis, Lynne, Shaywitz, Adam J., Yang, Ke, O’Neill, Charles A.
Publicado no Clin Pharmacokinet (2014)

Delivery of SAR 1118 to the Retina via Ophthalmic Drops and its Effectiveness in a Rat Streptozotocin (STZ) Model of Diabetic Retinopathy (DR)

Por Rao, Vidhya R., Prescott, Elizabeth, Shelke, Namdev B., Trivedi, Ruchit, Thomas, Peter, Struble, Craig, Gadek, Tom, O'Neill, Charles A., Kompella, Uday B.
Publicado em 2010

Bi-modal Dose-dependent Cardiac Response to Tetrahydrobiopterin in Pressure-overload Induced Hypertrophy and Heart Failure

Por Moens, An L., Ketner, Elizabeth A., Takimoto, Eiki, Schmidt, Tim S., O'Neill, Charles A., Wolin, Michael S., Alp, Nicholas J, Channon, Keith M., Kass, David A.
Publicado em 2011

Biodistribution and Pharmacodynamics of Recombinant Human Alpha-L-Iduronidase (rhIDU) in Mucopolysaccharidosis Type I-Affected Cats Following Multiple Intrathecal Administrations

Por Vite, Charles H., Wang, Ping, Patel, Reema T., Walton, Raquel M., Walkley, Steven U., Sellers, Rani S., Ellinwood, N. Matthew, Cheng, Alphonsus S., White, Joleen T., O’Neill, Charles A., Haskins, Mark
Publicado em 2011

Enzyme replacement therapy attenuates disease progression in a canine model of late-infantile neuronal ceroid lipofuscinosis (CLN2 disease)

Por Katz, Martin L, Coates, Joan R, Sibigtroth, Christine M, Taylor, Jacob D, Carpentier, Melissa, Young, Whitney M, Wininger, Fred A, Kennedy, Derek, Vuillemenot, Brian R, O'Neill, Charles A
Publicado no J Neurosci Res (2014)

Evaluation of the Therapeutic Potential of a CNP Analog in a Fgfr3 Mouse Model Recapitulating Achondroplasia

Por Lorget, Florence, Kaci, Nabil, Peng, Jeff, Benoist-Lasselin, Catherine, Mugniery, Emilie, Oppeneer, Todd, Wendt, Dan J., Bell, Sean M., Bullens, Sherry, Bunting, Stuart, Tsuruda, Laurie S., O'Neill, Charles A., Di Rocco, Federico, Munnich, Arnold, Legeai-Mallet, Laurence
Publicado em 2012