Influenza Human Monoclonal Antibody 1F1 Interacts with Three Major Antigenic Sites and Residues Mediating Human Receptor Specificity in H1N1 Viruses

Most monoclonal antibodies (mAbs) to the influenza A virus hemagglutinin (HA) head domain exhibit very limited breadth of inhibitory activity due to antigenic drift in field strains. However, mAb 1F1, isolated from a 1918 influenza pandemic survivor, inhibits select human H1 viruses (1918, 1943, 194...

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Detalhes bibliográficos
Main Authors: Tsibane, Tshidi, Ekiert, Damian C., Krause, Jens C., Martinez, Osvaldo, Crowe, James E., Wilson, Ian A., Basler, Christopher F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516549/
https://ncbi.nlm.nih.gov/pubmed/23236279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003067
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